Histological Diagnosis of Implant-associated Pathologies Paperback by Veit Krenn, ISBN-13: 978-3662571880
[PDF eBook eTextbook]
- Publisher: Springer 2017
- Language: English
- 153 pages
- ISBN-10: 3662571889
- ISBN-13: 978-3662571880
This guide to the histological diagnosis of periprosthetic tissue pathologies in joint arthroplasty is intended to provide a concise, yet comprehensive introduction to the host soft tissue and bone reactions to implants and their wear particulate materials. It is also a practical aid for tissue sampling and processing for the optimal pathological analysis. The target audience comprises orthopedic surgeons, either in practice or in training, as well as clinicians, radiologists, pathologists, and biomechanical engineers who are interested in understanding the details of the histological examination and report.
The text is divided into short chapters providing (a) a broad overview and sub-
typing of the expanded synovial-like interface membrane (SLIM) proposed as a standardized international classification of pathological changes, (b) criteria for the histological diagnosis of implant infection, (c) response patterns of hypersensitivity/allergic reactions and toxic inflammatory reactions to wear particles and in particular corrosion products, (d) an algorithm for the identification of particles with subclassifications according to their dimensions and morphological features, (e) a practical workflow for the collection and processing of tissue samples, and (f) future perspectives aimed at decreasing the risk of complications and improving outcome with an early and accurate histological diagnosis.
Numerous illustrations from our extensive archive of cases are provided for a
direct depiction of the criteria used for the identification of both SLIM and particles. Selected references are also provided without the claim of being exhaustive and with the aim of stimulating interest and discussion.
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