Essential Biochemistry 3rd Edition by Charlotte W. Pratt, ISBN-13: 978-1118083505
[PDF eBook eTextbook]
Publisher: Wiley; 3 edition (January 4, 2013)
Essential Biochemistry, 3rd Edition is comprised of biology, pre-med and allied health topics and presents a broad, but not overwhelming, base of biochemical coverage that focuses on the chemistry behind the biology. Furthermore, it relates the chemical concepts that scaffold the biology of biochemistry, providing practical knowledge as well as many problem-solving opportunities to hone skills. Key Concepts and Concept Review features help students to identify and review important takeaways in each section.
The images on the cover represent the scope of modern biochemistry, which seeks to characterize the molecules and reactions of life. In all organisms, genetic information—in the form of a sequence of nucleotides in DNA—is selectively expressed, as shown by the lighted spots of the DNA microarray in the background. Genetic information directs the synthesis of proteins. Each protein has a unique shape that can be visualized in three dimensions, as depicted by the blue surface model, and also has a unique metabolic function. For example, the protein shown on the cover is an enzyme whose activity contributes to the uncontrolled growth of cancer cells. Biochemists build on their knowledge of molecular structure and function to design compounds that can selectively interact with proteins in order to modulate their behavior. In this example (discussed in Box 10-B on page 280), the drug imatinib is shown as a green shape that fits snugly into the active site of the enzyme, blocking its activity and thereby inhibiting cancer growth.
Appreciating the structures and functions of biological molecules requires more than looking at pictures or reading about them. This book is designed not only to present information but also to help students develop the ability to answer questions, creating opportunities for them to explore and discover all aspects of biochemistry.
About the Author
Charlott Pratt received her Ph.D. in biochemistry from Duke University. She did post-doctoral research at the University of North Carolina at Chapel Hill and has contributed to numerous primary research articles and reviews. She is presently in the Department of Chemistry at Seattle Pacific University. She is co-author with Donald Voet and Judith Voet of Fundamentals of Biochemistry, also published by Wiley.
Kathleen Cornely received her Ph.D. in biochemistry from Cornell University. She has published numerous research articles and is presently Professor in the Department of Chemistry and Biochemistry at Providence College. She is a member of the Educational and Professional Development Committee of the American Society for Biochemistry and Molecular Biology and is on the editorial borad for the journal, Biochemistry and Molecular Biology Education.
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