Goldfrank’s Toxicologic Emergencies 11th Edition by Lewis S. Nelson, ISBN-13: 978-1259859618

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Goldfrank’s Toxicologic Emergencies 11th Edition by Lewis S. Nelson, ISBN-13: 978-1259859618

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• Publisher: ‎ McGraw Hill / Medical; 11th edition (April 11, 2019)
• Language: ‎ English
• 2104 pages (Large file size: 55 MB)
• ISBN-10: ‎ 1259859614
• ISBN-13: ‎ 978-1259859618

The best edition yet of the landmark text in medical toxicology.

A Doody’s Core Title for 2022!

Covering every aspect of poison management, this indispensable case-based resource has been thoroughly refreshed to deliver evidence-based principles viewed through the lens of an active bedside clinical practice. In no other reference will you find such a diverse roster of esteemed editors and authors who deliver expert insights into every type of toxicologic emergency, whether due to substance abuse or exposure to toxins.

Fully referenced and supported by a cohesive organization and full-color format, Goldfrank’s begins with a historical perspective on medical toxicology principles and the general approach to the patient. It then progresses to the fundamental principles of medical toxicology, encompassing biochemical and molecular concepts; the effect of xenobiotics on vital organs and body systems; and toxicologic principles in special populations.

The Eleventh Edition of Goldfrank’s Toxicologic Emergencies is the most rigorous volume to date, driven by a precise analysis of the latest medical literature and complex cases designed to facilitate differential diagnosis.

New to this Edition:

• Additional cases and “Special Considerations” chapters designed to enhance clinical decision-making and patient outcomes

• New “Antidotes in Depth” provides timely, critical information on toxicologic treatment strategies

• New content on toxicogenomics explores its increasingly important role in predictive toxicology

• Chapter-ending bulleted summaries of key points

• Updated coverage of synthetics such as “K2”

• Revised chapters on medical, clinical, and chemical toxicology include updated insights on poison emergencies, treatment strategies, and risk assessment tools

Table of Contents:

Cover

Title Page

Copyright Page

Dedication

Contents

Contributors

Preface

Acknowledgments

1. Historical Principles and Perspectives

2. Toxicologic Misfortunes and Catastrophes in History

Part A The General Approach to the Patient

Case Study 1

3. Initial Evaluation of the Patient: Vital Signs and Toxic Syndromes

Case Study 2

4. Principles of Managing the Acutely Poisoned or Overdosed Patient

SC1. Principles of Antidote Stocking

5. Techniques Used to Prevent Gastrointestinal Absorption

SC2. Decontamination Principles: Prevention of Dermal, Ophthalmic, and Inhalational Absorption

A1. Activated Charcoal

A2. Whole-Bowel Irrigation and Other Intestinal Evacuants

6. Principles and Techniques Applied to Enhance Elimination

7. Laboratory Principles

8. Principles of Diagnostic Imaging

9. Pharmacokinetic and Toxicokinetic Principles

Part B The Fundamental Principles of Medical Toxicology

Section I Biochemical and Molecular Concepts

10. Chemical Principles

11. Biochemical and Metabolic Principles

12. Fluid, Electrolyte, and Acid–Base Principles

13. Neurotransmitters and Neuromodulators

14. Withdrawal Principles

Section II Pathophysiologic Basis: Organ Systems

Case Study 3

15. Cardiologic Principles I: Electrophysiologic and Electrocardiographic Principles

16. Cardiologic Principles II: Hemodynamics

Case Study 4

17. Dermatologic Principles

SC3. Transdermal Toxicology

18. Gastrointestinal Principles

19. Genitourinary Principles

20. Hematologic Principles

21. Hepatic Principles

Case Study 5

22. Neurologic Principles

23. Oncologic Principles

24. Ophthalmic Principles

25. Otolaryngologic Principles

26. Psychiatric Principles

SC4. Patient Violence

27. Renal Principles

28. Respiratory Principles

29. Thermoregulatory Principles

Section III Special Populations

30. Reproductive and Perinatal Principles

31. Pediatric Principles

Case Study 6

32. Geriatric Principles

Part C The Clinical Basis of Medical Toxicology

Section I

A. Analgesics and Antiinflammatory Medications

33. Acetaminophen

A3. N-Acetylcysteine

34. Colchicine, Podophyllin, and the Vinca Alkaloids

35. Nonsteroidal Antiinflammatory Drugs

36. Opioids

A4. Opioid Antagonists

SC5. Internal Concealment of Xenobiotics

SC6. Prevention, Treatment, and Harm Reduction Approaches to Opioid Overdoses

37. Salicylates

A5. Sodium Bicarbonate

B. Food, Diet, and Nutrition

38. Botulism

A6. Botulinum Antitoxin

39. Food Poisoning

40. Dieting Xenobiotics and Regimens

41. Athletic Performance Enhancers

42. Essential Oils

43. Plant- and Animal-Derived Dietary Supplements

44. Vitamins

45. Iron

A7. Deferoxamine

C. Pharmaceuticals

46. Pharmaceutical Additives

47. Antidiabetics and Hypoglycemics/Antiglycemics

A8. Dextrose (D-Glucose)

A9. Octreotide

48. Antiepileptics

A10. L-Carnitine

Case Study 7

49. Antihistamines and Decongestants

A11. Physostigmine Salicylate

50. Chemotherapeutics

51. Methotrexate, 5-Fluorouracil, and Capecitabine

A12. Folates: Leucovorin (Folinic Acid) and Folic Acid

A13. Glucarpidase (Carboxypeptidase G2)

A14. Uridine Triacetate

SC7. Intrathecal Administration of Xenobiotics

SC8. Extravasation of Xenobiotics

52. Antimigraine Medications

53. Thyroid and Antithyroid Medications

D. Antimicrobials

54. Antibacterials, Antifungals, and Antivirals

55. Antimalarials

56. Antituberculous Medications

A15. Pyridoxine

E. Cardiopulmonary Medications

57. Antidysrhythmics

A16. Magnesium

58. Antithrombotics

A17. Prothrombin Complex Concentrates and Direct Oral Anticoagulant Antidotes

A18. Vitamin K1

A19. Protamine

Case Study 8

59. β-Adrenergic Antagonists

A20. Glucagon

60. Calcium Channel Blockers

A21. High-Dose Insulin

61. Miscellaneous Antihypertensives and Pharmacologically Related Agents

62. Cardioactive Steroids

A22. Digoxin-Specific Antibody Fragments

63. Methylxanthines and Selective β2-Adrenergic Agonists

F. Anesthetics and Related Medications

64. Local Anesthetics

A23. Lipid Emulsion

65. Inhalational Anesthetics

66. Neuromuscular Blockers

A24. Dantrolene Sodium

G. Psychotropic Medications

67. Antipsychotics

68. Cyclic Antidepressants

69. Serotonin Reuptake Inhibitors and Atypical Antidepressants

70. Lithium

71. Monoamine Oxidase Inhibitors

72. Sedative–Hypnotics

A25. Flumazenil

H. Substances of Abuse

73. Amphetamines

74. Cannabinoids

75. Cocaine

A26. Benzodiazepines

76. Ethanol

A27. Thiamine Hydrochloride

77. Alcohol Withdrawal

78. Disulfiram and Disulfiramlike Reactions

79. Hallucinogens

80. γ-Hydroxybutyric Acid (γ-Hydroxybutyrate)

81. Inhalants

82. Nicotine

83. Phencyclidine and Ketamine

I. Metals

Case Study 9

84. Aluminum

85. Antimony

86. Arsenic

A28. Dimercaprol (British Anti-Lewisite or Bal)

87. Bismuth

88. Cadmium

89. Cesium

90. Chromium

91. Cobalt

92. Copper

93. Lead

A29. Succimer (2,3-Dimercaptosuccinic Acid) and DMPS (2,3-Dimercapto-1-Propanesulfonic Acid)

A30. Edetate Calcium Disodium (CaNa2EDTA)

94. Manganese

95. Mercury

96. Nickel

97. Selenium

98. Silver

99. Thallium

A31. Prussian Blue

100. Zinc

J. Household Products

101. Antiseptics, Disinfectants, and Sterilants

102. Camphor and Moth Repellents

103. Caustics

104. Hydrofluoric Acid and Fluorides

A32. Calcium

105. Hydrocarbons

Case Study 10

106. Toxic Alcohols

A33. Fomepizole

A34. Ethanol

SC9. Diethylene Glycol

K. Pesticides

Case Study 11

107. Barium

108. Fumigants

109. Herbicides

110. Insecticides: Organic Phosphorous Compounds and Carbamates

A35. Atropine

A36. Pralidoxime

111. Insecticides: Organic Chlorines, Pyrethrins/Pyrethroids, and Insect Repellents

112. Phosphorus

113. Sodium Monofluoroacetate and Fluoroacetamide

114. Strychnine

L. Natural Toxins and Envenomations

115. Arthropods

A37. Antivenom: Spider

A38. Antivenom: Scorpion

116. Marine Envenomations

117. Mushrooms

118. Plants

119. Native (US) Venomous Snakes and Lizards

A39. Antivenom for North American Venomous Snakes (Crotaline and Elapid)

SC10. Exotic Nonnative Snake Envenomations

M. Occupational and Environmental Toxins

Case Study 12

120. Smoke Inhalation

Case Study 13

121. Simple Asphyxiants and Pulmonary Irritants

122. Carbon Monoxide

A40. Hyperbaric Oxygen

123. Cyanide and Hydrogen Sulfide

A41. Hydroxocobalamin

A42. Nitrites (Amyl and Sodium) and Sodium Thiosulfate

124. Methemoglobin Inducers

A43. Methylene Blue

125. Nanotoxicology

N. Disaster Preparedness

126. Chemical Weapons

127. Biological Weapons

128. Radiation

A44. Potassium Iodide

A45. Pentetic Acid or Pentetate (Zinc or Calcium) Trisodium (DTPA)

Part D Population Health

Section I Poison Control Centers, Health Systems, and Epidemiology

129. Poison Prevention and Education

130. Poison Control Centers and Poison Epidemiology

131. Principles of Occupational Toxicology: Diagnosis and Control

132. Hazardous Materials Incident Response

133. Risk Assessment and Risk Communication

Case Study 14

134. Medication Safety and Adverse Drug Events

135. Drug Development, Adverse Drug Events, and Postmarketing Surveillance

136. International Perspectives on Medical Toxicology

137. Principles of Epidemiology and Research Design

Section II Legal Aspects of Toxicology

138. Risk Management and Legal Principles

139. Medicolegal Interpretive Toxicology

SC11. Assessment of Ethanol-Induced Impairment

140. Postmortem Toxicology

SC12. Organ Procurement from Poisoned Patients

Index

Lewis S. Nelson, MD is Professor and Chair, Department of Emergence Medicine, Rutgers New Jersey Medical School, Chief of Service, Emergency Department, University Hospital.

Robert S. Hoffman, MD is Professor of Emergency Medicine and Medicine, Director, Division of Medical Toxicology, New York University School of Medicine, Attending Physician, Emergency Medicine, Bellevue Hospital Center and New York University Langone Medical Center, Consultant, New York City Poison Center.

Mary Ann Howland, PharmD is Clinical Professor of Pharmacy, St. John’s University College of Pharmacy and Health Sciences, Adjunct Professor of Emergency Medicine, New York University School of Medicine, Bellevue Hospital Center and New York University Langone Medical Center, Senior Consultant, New York City Poison Center.

Neal A. Lewin, MD is Druckenmiller Professor of Emergency Medicine and Professor of Medicine (Pharmacology), New York University School of Medicine, Director, Didactic Education, Emergency Medicine Residency, Attending Physician, Emergency Medicine and Internal Medicine, Bellevue Hospital Center and New York University Langone Medical Center, Consultant, New York City Poison Center.

Silas W. Smith, MD is Associate Professor of Emergency Medicine, Chief of Safety and Quality, Department of Emergency Medicine, Associate Director of Medical Toxicology Fellowship Program, New York University School of Medicine, New York City Poison Control Center, Attending Physician Bellevue Hospital Center and New York University Langone Medical Center.

Lewis R. Goldfrank, MD is the Herbert W. Adams Professor of Emergency Medicine, Ronald O. Perelman Department of Emergency Medicine, Director, Emergency Medicine, Bellevue Hospital Center and New York University Medical Center, Medical Director, New York City Poison Center.

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