Step-Up to Medicine 6th North American Edition by Steven Agabegi, ISBN-13: 978-1975192716

Step-Up to Medicine 6th North American Edition by Steven Agabegi, ISBN-13: 978-1975192716

[PDF eBook eTextbook]

• Publisher: ‎ LWW; Sixth, North American edition (May 18, 2023)
• Language: ‎ English
• ISBN-10: ‎ 1975192710
• ISBN-13: ‎ 978-1975192716

Make the most of your study time and confidently take the next step in your medical career with this bestselling review.

Step-Up to Medicine, 6th Edition, makes it easy to find information fast and take a confident next step toward a successful medical career. Ideal for preparing for clerkships or clinical rotations, shelf exams, and the USMLE Step 2, this bestselling volume in the popular Step-Up series provides a high-yield review of medicine in a concise, comprehensive approach.

This 6th Edition is thoroughly updated and enhanced throughout. Clinical pearls, full-color illustrations, and “Quick Hits” provide essential information in an efficient, easy-to-remember manner to ensure excellence on exams and confidence in clinical settings, and a 100-question practice exam reinforces exam readiness and boosts test-taking confidence.

Table of Contents:

Cover
Title Page
Copyright
Advisory Board
Reviewers
Preface
Contents
1 Diseases of the Cardiovascular System
Chest Pain
Ischemic Heart Disease
Stable Angina Pectoris
Acute Coronary Syndromes (ACS)
Variant (Prinzmetal) Angina
Congestive Heart Failure
Acute Decompensated Heart Failure
Arrhythmias
Terminology
Premature Complexes
Tachyarrhythmias
Atrial Fibrillation
Atrial Flutter
Multifocal Atrial Tachycardia
Paroxysmal Supraventricular Tachycardia
Wolff–Parkinson–White (WPW) Syndrome
Summary of Atrial Tachyarrhythmias (Figure 1-11)
Ventricular Tachycardia
Ventricular Fibrillation
Bradyarrhythmias
Sinus Bradycardia
Sick Sinus Syndrome
AV Block
Diseases of the Heart Muscle
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Restrictive Cardiomyopathy
Myocarditis
Pericardial Diseases
Acute Pericarditis
Constrictive Pericarditis
Pericardial Effusion
Cardiac Tamponade
Valvular Heart Disease
Mitral Stenosis
Aortic Stenosis
Aortic Regurgitation
Mitral Regurgitation
Tricuspid Regurgitation
Mitral Valve Prolapse
Rheumatic Heart Disease
Infective Endocarditis
Nonbacterial Thrombotic Endocarditis (Marantic Endocarditis)
Nonbacterial Verrucous Endocarditis (Libman–Sacks Endocarditis)
Congenital Heart Diseases
Atrial Septal Defect
Ventricular Septal Defect
Coarctation of the Aorta
Patent Ductus Arteriosus
Tetralogy of Fallot
Diseases of the Vasculature
Hypertensive Emergency
Aortic Dissection
Abdominal Aortic Aneurysm
Peripheral Arterial Disease
Acute Arterial Occlusion
Cholesterol Embolization Syndrome
Deep Venous Thrombosis
Chronic Venous Insufficiency (Venous Stasis Disease)
Superficial Thrombophlebitis
Cardiac Neoplasms
Atrial Myxoma
Shock
Basics of Shock
Cardiogenic Shock
Hypovolemic Shock
Septic Shock
Neurogenic Shock
Obstructive Shock
Syncope
2 Diseases of the Pulmonary System
Obstructive Lung Diseases
Chronic Obstructive Pulmonary Disease
Asthma
Bronchiectasis
Cystic Fibrosis
Lung Neoplasms
Lung Cancer
Solitary Pulmonary Nodule
Mediastinal Masses
Diseases of the Pleura
Pleural Effusion
Empyema
Pneumothorax
Tension Pneumothorax
Malignant Mesothelioma
Interstitial Lung Disease
Overview
Interstitial Lung Diseases Associated With Granulomas
Environmental Lung Disease/Pneumoconiosis
Interstitial Lung Disease Associated With Hypersensitivity
Alveolar Filling Disease
Miscellaneous Interstitial Lung Diseases
Respiratory Failure
Acute Respiratory Failure
Acute Respiratory Distress Syndrome
Mechanical Ventilation
Diseases of the Pulmonary Vasculature
Pulmonary Hypertension
Cor Pulmonale
Pulmonary Embolism
Miscellaneous Topics
Pulmonary Aspiration
Dyspnea
Hemoptysis
3 Diseases of the Gastrointestinal System
Diseases of the Colon
Colorectal Cancer
Colonic Polyps
Diverticulosis
Angiodysplasia of the Colon (Arteriovenous Malformations, Vascular Ectasia)
Acute Mesenteric Ischemia
Chronic Mesenteric Ischemia
Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome)
Colonic Volvulus
Diseases of the Liver
Acute Liver Failure
Cirrhosis
Wilson Disease
Hemochromatosis
Hepatocellular Adenoma
Hepatic Hemangiomas
Focal Nodular Hyperplasia
Hepatocellular Carcinoma (Malignant Hepatoma)
Nonalcoholic Fatty Liver Disease (NAFLD)
Hemobilia
Liver Cysts
Liver Abscess
Budd–Chiari Syndrome
Jaundice
Liver Lab Tests
Diseases of the Gallbladder and Biliary Tract
Cholelithiasis
Acute Cholecystitis
Acalculous Cholecystitis
Choledocholithiasis
Cholangitis
Carcinoma of the Gallbladder
Primary Sclerosing Cholangitis
Primary Biliary Cholangitis
Cholangiocarcinoma
Biliary Cysts
Biliary Stricture
Biliary Dyskinesia
Diseases of the Appendix
Acute Appendicitis
Neuroendocrine Tumors (NETs) and Carcinoid Syndrome
Diseases of the Pancreas
Acute Pancreatitis
Chronic Pancreatitis
Pancreatic Cancer
Gastrointestinal Bleeding
Diseases of the Esophagus
Esophageal Cancer
Achalasia
Diffuse Esophageal Spasm
Esophageal Hiatal Hernias
Mallory–Weiss Syndrome
Plummer–Vinson Syndrome (Upper Esophageal Webs)
Esophageal Rings (Schatzki Ring)
Esophageal Diverticula
Esophageal Perforation
Diseases of the Stomach
Peptic Ulcer Disease
Acute Gastritis
Chronic Gastritis
Gastric Cancer
Gastric Lymphoma
Diseases of the Small Intestine
Small Bowel Obstruction
Paralytic Ileus
Celiac Disease
Whipple’ Disease
Tropical Sprue
Inflammatory Bowel Disease
Crohn Disease
Ulcerative Colitis
4 Endocrine and Metabolic Diseases
Diseases of the Pancreas
Diabetes Mellitus
Chronic Complications of Diabetes Mellitus
Acute Complications of Diabetes Mellitus
Obesity
Hypoglycemia
Insulinoma
Zollinger–Ellison Syndrome (ZES, Gastrinoma)
Glucagonoma
Somatostatinoma
VIPoma (Verner–Morrison or Watery Diarrhea, Hypokalemia, Achlorhydria Syndrome)
Diseases of the Thyroid Gland
Hyperthyroidism
Thyroid Storm
Hypothyroidism
Thyroiditis
Thyroid Nodules
Thyroid Cancer
Diseases of the Pituitary Gland
Pituitary Adenomas
Hyperprolactinemia
Acromegaly
Craniopharyngioma
Hypopituitarism
Diabetes Insipidus
Syndrome of Inappropriate Secretion of Antidiuretic Hormone
Diseases of the Parathyroid Glands
Hypoparathyroidism
Primary Hyperparathyroidism
Diseases of the Adrenal Glands
Cushing Syndrome
Pheochromocytoma
Primary Hyperaldosteronism
Adrenal Insufficiency
Congenital Adrenal Hyperplasia
5 Diseases of the Central and Peripheral Nervous Systems
Cerebrovascular Disease
Ischemic Stroke
Hemorrhagic Stroke
Seizures
Movement Disorders
Parkinson Disease
Huntington Chorea
Tremor
Ataxia
Restless Leg Syndrome
Tourette Syndrome
Dementia
Overview
Alzheimer Disease
Altered Mental Status
Acute Encephalopathy
Coma
Demyelinating Disease
Multiple Sclerosis
Guillain–Barré Syndrome
Neuromuscular Diseases
Myasthenia Gravis
Duchenne Muscular Dystrophy
Becker Muscular Dystrophy
Neurocutaneous Syndromes
Neurofibromatosis Type I (von Recklinghausen Disease)
Neurofibromatosis Type II
Tuberous Sclerosis
Sturge–Weber Syndrome
Von Hippel–Lindau Disease
Spinal Cord Diseases
Syringomyelia
Brown-Séquard Syndrome
Transverse Myelitis
Horner Syndrome
Poliomyelitis
Miscellaneous Conditions
Vertigo
Amyotrophic Lateral Sclerosis or “Lou Gehrig Disease”
Aphasia
Bell Palsy
Trigeminal Neuralgia (Tic Douloureux)
How to Localize a Neurologic Lesion
6 Connective Tissue and Joint Diseases
Connective Tissue Diseases
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Systemic Sclerosis (Scleroderma)
Sjögren Syndrome
Mixed Connective Tissue Disease
Crystal-Induced Arthritides
Gout
Pseudogout (Calcium Pyrophosphate Deposition Disease)
Myopathies and Pain Syndromes
Idiopathic Inflammatory Myopathies
Inclusion Body Myositis
Polymyalgia Rheumatica
Fibromyalgia
Seronegative Spondyloarthropathies
Ankylosing Spondylitis
Reactive Arthritis
Psoriatic Arthritis
Vasculitis
Vasculitis Overview (Figure 6-9)
Large-Vessel Vasculitides
Medium-Vessel Vasculitides
ANCA-Associated Small-Vessel Vasculitides
Immune Complex Small-Vessel Vasculitides
Variable-Vessel Vasculitis
7 Diseases of the Renal and Genitourinary System
Renal Failure
Acute Kidney Injury (AKI)
Chronic Kidney Disease
Dialysis
Proteinuria and Hematuria
Proteinuria
Hematuria
Glomerular Disease
Overview
Primary Glomerular Disorders (see Figure 7-4)
Secondary Glomerular Disorders
Tubulointerstitial Diseases
Acute Interstitial Nephritis
Renal Papillary Necrosis
Renal Tubular Acidosis
Fanconi Syndrome
Renal Cystic Diseases
Autosomal Dominant Polycystic Kidney Disease
Autosomal Recessive Polycystic Kidney Disease
Medullary Sponge Kidney
Simple Renal Cysts
Renal Vascular Disease
Renal Artery Stenosis (Renovascular Hypertension)
Renal Vein Thrombosis
Atheroembolic Disease of the Renal Arteries
Hypertensive Nephrosclerosis
Sickle Cell Nephropathy
Stones and Obstructions
Nephrolithiasis
Urinary Tract Obstruction
Neoplasms
Prostate Cancer
Renal Cell Carcinoma
Bladder Cancer
Testicular Cancer
Penile Cancer
Miscellaneous Conditions
Testicular Torsion
Epididymitis
8 Fluids, Electrolytes, and Acid–Base Disorders
Volume Disorders
Approach to Volume Disorders
Hypovolemia
Hypervolemia
Sodium
Overview of Sodium Homeostasis
Hyponatremia
Hypernatremia
Calcium
Calcium Metabolism
Hypocalcemia
Hypercalcemia
Potassium
Potassium Metabolism
Hypokalemia
Hyperkalemia
Magnesium
Overview
Hypomagnesemia
Hypermagnesemia
Phosphate
Overview
Hypophosphatemia
Hyperphosphatemia
Acid–Base Disorders
Metabolic Acidosis
Metabolic Alkalosis
Respiratory Acidosis
Respiratory Alkalosis
9 Hematologic Diseases and Neoplasms
Anemias
Basics of Anemia
Microcytic Anemias
Iron-Deficiency Anemia
Thalassemias
Sideroblastic Anemia
Normocytic Anemias
Anemia of Chronic Disease
Aplastic Anemia
Macrocytic Anemias
Vitamin B12 Deficiency
Folate Deficiency
Hemolytic Anemias
Overview
Sickle Cell Disease
Hereditary Spherocytosis
Glucose-6-Phosphate Dehydrogenase Deficiency
Autoimmune Hemolytic Anemia
Paroxysmal Nocturnal Hemoglobinuria
Platelet Disorders
Thrombocytopenia
Immune (Idiopathic) Thrombocytopenic Purpura
Thrombotic Thrombocytopenic Purpura
Heparin-Induced Thrombocytopenia, Type 2
Bernard–Soulier Syndrome
Glanzmann Thrombasthenia
Disorders of Coagulation
von Willebrand Disease
Hemophilia A
Hemophilia B
Disseminated Intravascular Coagulation
Vitamin K Deficiency
Coagulopathy of Liver Disease
Hypercoagulable States
Anticoagulation
Heparin
Low–Molecular-Weight Heparin
Warfarin
Direct Oral Anticoagulants
Oncology
Epidemiology
Cancer Prevention and Screening
Principles of Cancer Staging and Therapy
Breast Cancer
Plasma Cell Disorders
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Waldenström Macroglobulinemia
Lymphomas
Hodgkin Lymphoma
Non-Hodgkin Lymphoma
Leukemias
Acute Leukemias
Chronic Lymphocytic Leukemia
Chronic Myeloid Leukemia
Myeloproliferative Disorders
Polycythemia Vera
Myelodysplastic Syndromes
Essential Thrombocythemia
10 Infectious Diseases
Infections of the Upper and Lower Respiratory Tracts
Pneumonia
Ventilator-Associated Pneumonia
Lung Abscess
Tuberculosis
Influenza
SARS-CoV-2 (COVID-19)
Infections of the Central Nervous System
Meningitis
Encephalitis
Infections of the Gastrointestinal Tract (see also Chapter 3)
Viral Hepatitis
Botulism
Intra-Abdominal Abscess
Clostridioides difficile Infection (CDI)
Infections of the Genitourinary Tract
Cystitis (Lower Urinary Tract Infections)
Pyelonephritis
Prostatitis
Sexually Transmitted Diseases
Condyloma Acuminata (Anogenital Warts)
Chlamydia
Gonorrhea
HIV and AIDS
Herpes Simplex
Syphilis
Chancroid
Lymphogranuloma Venereum
Pediculosis Pubis (Pubic Lice)
Skin and Soft Tissue Infections (SSTIs)
Cellulitis
Erysipelas
Necrotizing Fasciitis
Lymphadenitis or Lymphangitis
Tetanus
Infections of the Bones and Joints
Osteomyelitis
Acute Infectious Arthritis
Zoonoses and Arthropod-Borne Diseases
Lyme Disease
Rocky Mountain Spotted Fever (RMSF)
Malaria
Rabies
Other Zoonoses
Common Fungal Infections
Candidiasis
Aspergillus
Cryptococcosis
Other Fungal Infections
Common Parasitic Infections
Fever and Sepsis
Fever of Unknown Origin
Toxic Shock Syndrome
Catheter-Related Bloodstream Infections (CRBSIs)
Neutropenic Fever
Miscellaneous Infections
Infectious Mononucleosis
11 Diseases of the Skin and Hypersensitivity Disorders
KEY DEFINITIONS
COMMON SKIN DISORDERS
Acneiform Eruptions
Acne Vulgaris
Rosacea
Hidradenitis Suppurativa
Atopic and Contact Dermatitis
Atopic Dermatitis (Eczema)
Contact Dermatitis
Papulosquamous Eruptions
Psoriasis
Seborrheic Dermatitis
Pityriasis Rosea
Lichen Planus
Allergic Reactions
Urticaria (Hives)
Angioedema
Anaphylaxis
Drug Reactions
Other Inflammatory and Autoimmune Disorders
Erythema Nodosum
Pyoderma Gangrenosum
Bullous Pemphigoid
Pemphigus Vulgaris
Vitiligo
SKIN CONDITIONS RELATED TO INFECTIONS AND INFESTATIONS
Warts
Molluscum Contagiosum
Herpes Zoster (Shingles)
Dermatophytes
Tinea Versicolor
Scabies
BENIGN AND MALIGNANT SKIN LESIONS
Benign Skin Lesions
Actinic Keratosis (Also Called Solar Keratosis)
Seborrheic Keratosis
Keratoacanthoma
Malignant Skin Lesions
Basal Cell Carcinoma
Squamous Cell Carcinoma
Melanoma
12 Ambulatory Medicine
Cardiovascular Diseases
Hypertension
Hyperlipidemias
Headache
Tension Headache
Cluster Headaches
Migraine
Upper Respiratory Diseases
Cough
Acute Bronchitis
The Common Cold
Sinusitis
Laryngitis
Sore Throat
Gastrointestinal Diseases
Dyspepsia
Gastroesophageal Reflux Disease
Diarrhea
Constipation
Irritable Bowel Syndrome
Nausea and Vomiting
Hemorrhoids
MUSCULOSKELETAL PROBLEMS
Overview of Musculoskeletal Examination Maneuvers
Low Back Pain
Common Disorders of the Cervical Spine
Knee Pain
Ankle Sprains
Tendinitis and Bursitis
Carpal Tunnel Syndrome
Osteoarthritis
Osteoporosis
Diseases of the Eye
Age-Related Macular Degeneration
Glaucoma
Cataracts
Red Eye
Conjunctivitis
Amaurosis Fugax
Sleep Disorders
Obstructive Sleep Apnea
Narcolepsy
Insomnia
Miscellaneous Topics
Obesity
Hearing Loss/Impaired Hearing
Urinary Incontinence
Fatigue
Erectile Dysfunction
Addiction Medicine
Overview of Substance Use Disorders (SUDs)
Alcohol Use Disorder
Opioid Use Disorder
Smoking
Health Maintenance
Appendix
Radiographic Interpretation
Chest Radiograph
Abdominal Radiographs
Electrocardiogram Interpretation
Electrocardiogram Pearls
Intravenous Therapy
Central Venous Line
Arterial Lines
Nutritional Support
Guide to Antibacterial Antibiotic Therapy
Physical Examination Pearls
Heart Sounds
Murmurs
Breath Sounds
Abdominal Examination
Neurologic Examination
Tumor Markers
Workup and Management of Common Problems
On the Wards
Hypotension
Hypertension
Chest Pain
Tachycardia
Oliguria
Fever in the Hospitalized Patient
Hypoglycemia
Change in Mental Status (Acute Encephalopathy)
Shortness of Breath/Acute Hypoxia
Basic Statistics and Evidence-Based Medicine
End-of-Life Issues and Informed Consent
Questions
Answers
Index

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