Genetic Association Studies: Background, Conduct, Analysis, Interpretation, ISBN-13: 978-0815344636


Genetic Association Studies: Background, Conduct, Analysis, Interpretation, ISBN-13: 978-0815344636

[PDF eBook eTextbook]

  • Publisher: ‎ Garland Science; 1st edition (September 26, 2016)
  • Language: ‎ English
  • 230 pages
  • ISBN-10: ‎ 9780815344636
  • ISBN-13: ‎ 978-0815344636

Genetic Association Studies is designed for students of public health, epidemiology, and the health sciences, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Table of Contents:

1. Primer on Molecular Genetics

2. Primer on Medical Genetics

3. Primer on Population Genetics

4. Epidemiologic Principles and Genetic Association Studies

5. Environmental Epidemiology in the Context of Genetic Epidemiology

6. Elementary Statistical Concepts

7. Genotyping Methods and Errors

8. Candidate Gene Studies and Genome-Wide Association Studies

9. Statistical Analysis of Genetic Association Study Results

10. Bioinformatics for the Interpretation of Genetic Association Study Results

11. Genetic Risk Profiling and Medical Applications of Genetic Associations

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