Charney & Nestler’s Neurobiology of Mental Illness 5th Edition by Dennis S. Charney, ISBN-13: 978-0190681425

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Charney & Nestler’s Neurobiology of Mental Illness 5th Edition by Dennis S. Charney, ISBN-13: 978-0190681425

[PDF eBook eTextbook]

• Publisher: ‎ Oxford University Press; 5th edition (January 17, 2018)
• Language: ‎ English
• 1024 pages
• ISBN-10: ‎ 019068142X
• ISBN-13: ‎ 978-0190681425

In the years following publication of the DSM-5®, the field of psychiatry has seen vigorous debate between the DSM’s more traditional, diagnosis-oriented approach and the NIMH’s more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler’s Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.

In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text.

In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.

Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress.

The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5®, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Table of Contents:

Title Page

Copyright Page

Contents

Contributors

Section 1 Emerging and Established Technologies

1. Genetic Methodologies and Applications

2. Network Methods for Elucidating the Complexity of Common Human Diseases

3. The Human Brain and Its Epigenomes

4. Methods for In Vivo Gene Manipulation

5. Application of Stem Cells to Understanding Psychiatric Disorders

6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges

7. In Vivo Circuit Analysis

8. Magnetic Resonance Methodologies

9. PET Brain Imaging Methodologies

10. Neuromodulation and Psychiatric Disorders

11. The Neurobiology of Sleep

SECTION 2 PSYCHOTIC DISORDERS

12. Diagnosis and Epidemiology of Psychotic Disorders

13. Genetics of Schizophrenia and Bipolar Disorder

14. Neuroimaging of Psychotic Disorders

15. Animal and Cellular Models of Psychotic Disorders

16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies

17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies

18. Cellular Mechanisms of Psychotic Disorders: Human Studies

19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies

20. The Neurobiology and Treatment of Bipolar Disorder

21. Novel Approaches for Treating Psychotic Disorders

22. Current Treatments for Psychotic Disorders

SECTION 3 DEPRESSION

23. Diagnosis and Epidemiology of Depression

24. Genetics of Depression

25. Neuroimaging of Depression

26. Animal Models of Mood Disorders

27. Neurotrophic Mechanisms of Depression: Animal and Human Studies

28. Immune Mechanisms of Depression

29. Neuroendocrine Mechanisms of Depression: Clinical and Preclinical Evidence

30. New Approaches for Treating Depression

31. Current Treatments for Depression

SECTION 4 ANXIETY DISORDERS

32. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma and Stressor-Related Disorders

33. Genetics of Anxiety Disorders

34. Functional Neurocircuitry and Neuroimaging Studies of Anxiety Disorders

35. Animal Models and Assays Probing Anxiety Related Behaviors and Neural Circuits

36. What Are Fear and Anxiety? Listening to the Brain

37. Synaptic and Circuit Mechanisms of Anxiety Disorders: Animal and Human Studies

38. The Neurobiology of Resilience

39. Novel Approaches for Treating Anxiety Disorders

40. Current and Experimental Treatments for Anxiety Disorders

SECTION 5 SUBSTANCE USE DISORDERS

41. Epidemiology of Substance Use Disorders

42. The Genetic Basis of Addictive Disorders

43. Animal Models of Addiction

44. Reward Circuitry and Drug Addiction

45. Molecular Neuroimaging in Addictive Disorders

46. Cellular and Molecular Mechanisms of Addiction

47. Brain Development and the Risk for Substance Abuse

48. Novel Approaches for Treating Addiction

49. Current Approved Pharmacotherapies for Substance Use Disorders

SECTION 6 DEMENTIA

50. Diagnosis and Epidemiology of Dementia

51. Genetics of Dementia

52. Neuroimaging and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

53. Animal Models of Alzheimer’s Disease

54. Cellular Mechanisms of Dementia: Animal and Human Studies

55. Neurobiology of Lewy Body Dementias: Animal and Human Studies

56. Neurobiology of FTD: Animal and Human Studies

57. Current Treatments for Alzheimer’s Disease

SECTION 7 PEDIATRIC PSYCHIATRIC DISORDERS

58. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders

59. Genetics of Pediatric Psychiatric Disorders

60. Neuroimaging in Pediatric Psychiatric Disorders

61. Animal and Cellular Models of Pediatric Psychiatric Disorders

62. Neurodevelopmental Mechanisms of Pediatric Psychiatric Disorders: Animal and Human Studies

63. Neurobiology of Autism Spectrum Disorder and Intellectual Disability: Animal and Human Studies

64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies

65. The Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies

66. Neurobiology of Eating Disorders: Animal and Human Studies

67. Novel Approaches for Treating Pediatric Psychiatric Disorders

68. Current Treatments for Pediatric Psychiatric Disorders

SECTION 8 FUTURE OF PSYCHIATRIC DIAGNOSIS: TOWARD PRECISION PSYCHIATRY

69. DSM-5 Overview and Goals

70. The Present and Future of Psychiatric Diagnosis

71. The NIMH Research Domain Criteria Project: Toward Precision Medicine in Psychiatry

72. Computational Psychiatry and the Bayesian Brain

Index

Dennis S. Charney, MD

Anne and Joel Ehrenkranz, Dean,

Icahn School of Medicine at Mount Sinai

President for Academic Affairs

Mount Sinai Health System

Professor, Departments of Psychiatry, Neuroscience, and

Pharmacological Sciences

New York, NY

Joseph D. Buxbaum, PhD

G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences

Deputy chair, department of psychiatry

Director, Seaver Autism Center for research and treatment

Icahn School of Medicine at Mount Sinai

New York, NY

Pamela Sklar, MD, PhD

Mount Sinai professor of Psychiatric genomics

Chair, department of Genetics and Genomic Sciences Professor, Departments of Genetics and Genomic Sciences, Psychiatry, Neuroscience, and

Director, Center for Psychiatric Genomics

Icahn School of Medicine at Mount Sinai

New York, NY

Eric J. Nestler, MD, PhD

Nash Family Professor

Departments of Neuroscience and Psychiatry

Director, The Friedman Brain Institute

Dean for academic and scientific affairs

Icahn School of Medicine at Mount Sinai

New York, NY

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