Essentials of Nuclear Medicine and Molecular Imaging 7th Edition by Fred A. Mettler, ISBN-13: 978-0323483193

Description

Essentials of Nuclear Medicine and Molecular Imaging 7th Edition by Fred A. Mettler, ISBN-13: 978-0323483193

[PDF eBook eTextbook]

• Publisher: ‎ Elsevier; 7th edition (November 21, 2018)
• Language: ‎ English
• 560 pages
• ISBN-10: ‎ 0323483194
• ISBN-13: ‎ 978-0323483193

Covering both the fundamentals and recent developments in this fast-changing field, Essentials of Nuclear Medicine and Molecular Imaging, 7th Edition, is a must-have resource for radiology residents, nuclear medicine residents and fellows, nuclear medicine specialists, and nuclear medicine technicians. Known for its clear and easily understood writing style, superb illustrations, and self-assessment features, this updated classic is an ideal reference for all diagnostic imaging and therapeutic patient care related to nuclear medicine, as well as an excellent review tool for certification or MOC preparation.

• Provides comprehensive, clear explanations of everything from principles of human physiology, pathology, physics, radioactivity, radiopharmaceuticals, radiation safety, and legal requirements to hot topics such as new brain and neuroendocrine tumor agents and hybrid imaging, including PET/MR and PET/CT.
• Covers the imaging of every body system, as well as inflammation, infection and tumor imaging; pearls and pitfalls for every chapter; and pediatric doses and guidelines in compliance with the Image Gently and Image Wisely programs.
• Features a separate self-assessment section on differential diagnoses, imaging procedures and artifacts, and safety issues with unknown cases, questions, answers, and explanations.
• Includes new images and illustrations, for a total of 430 high-quality, multi-modality examples throughout the text.
• Reflects recent advances in the field, including updated nuclear medicine imaging and therapy guidelines • Updated dosimetry values and effective doses for all radiopharmaceuticals with new values from the 2015 International Commission on Radiological Protection • Updated information regarding advances in brain imaging, including amyloid, dopamine transporter and dementia imaging • Inclusion of Ga-68 DOTA PET/CT for neuroendocrine tumors • Expanded information on correlative and hybrid imaging with SPECT/CT • New myocardial agents • and more.
• Contains extensive appendices including updated comprehensive imaging protocols for routine and hybrid imaging, pregnancy and breastfeeding guidelines, pediatric dosages, non-radioactive pharmaceuticals used in interventional and cardiac stress imaging, and radioactivity conversion tables.

Table of Contents:

Cover image

Title Page

Table of Contents

Copyright

Dedication

Preface

Acknowledgments

1 Radioactivity, Radionuclides, and Radiopharmaceuticals

Basic Isotope Notation

Radionuclide Production

Radioactive Decay

Radionuclide Generator Systems

Radionuclides and Radiopharmaceuticals for Imaging

Radiopharmacy Quality Control

Unsealed Radionuclides Used for Therapy

Suggested Readings

2 Instrumentation and Quality Control

Geiger-Mueller Counter

Ionization Chamber

Sodium Iodide Well Counter

Single Probe Counting Systems

Dose Calibrator

Gamma Scintillation Camera

Single-Photon Emission Computed Tomography (SPECT)

SPECT/CT

Positron Emission Tomography (PET)

PET/CT

PET/MRI

Instrumentation Quality Control

Technical Artifacts

Suggested Readings

3 Central Nervous System

Radionuclide Brain Imaging

Cerebrospinal Fluid Imaging

Suggested Readings

4 Thyroid, Parathyroid, and Salivary Glands

Thyroid Radioiodine Uptake and Imaging

Iodine-131 Therapy in Benign Thyroid Disease

Parathyroid Imaging and Localization

Salivary Gland Imaging

Suggested Readings

5 Cardiovascular System

Anatomy and Physiology

SPECT Myocardial Perfusion Imaging

PET Cardiac Imaging

Radionuclide Imaging of Cardiac Function

Suggested Readings

6 Respiratory System

Anatomy and Physiology

Radiopharmaceuticals

Technique

Normal Lung Scan

Clinical Applications

Lung Scanning During Pregnancy

Deep Venous Imaging and Thrombus Detection

Suggested Readings

7 Gastrointestinal Tract

Liver-Spleen Imaging

Hepatic Blood Pool Imaging

Splenic Imaging

Gastrointestinal Bleeding Studies

Meckel Diverticulum Imaging

Hepatobiliary Imaging

Gastroesophageal Function Studies

Abdominal Shunt Evaluation

Suggested Readings

8 Skeletal System

Anatomy and Physiology

Radiopharmaceuticals

Technique

Normal Scan

Clinical Applications

Bone Marrow Imaging

Bone Mineral Measurements

Palliative Therapy of Painful Osseous Metastases

Suggested Readings

9 Genitourinary System and Adrenal Glands

Physiology

Radiopharmaceuticals

Radionuclide Renal Evaluation

Clinical Applications of Renal Imaging

Adrenal Gland Imaging

Suggested Readings

10 Non-PET Neoplasm Imaging and Radionuclide Therapy

Targeted Tumor Imaging

Nonspecific Tumor Imaging

Technetium-99m Sestamibi Tumor Imaging

Lymphoscintigraphy

Radionuclide Tumor Antibody Imaging and Therapy

Suggested Readings

11 Hybrid PET/CT Neoplasm Imaging

18F-FDG PET Imaging

Other PET Radionuclides

Suggested Readings

12 Inflammation and Infection Imaging

Radiolabeled Leukocytes

Gallium Imaging

Fluorine-18 Fluorodeoxyglucose PET/CT Imaging

Future Inflammation Agents

Suggested Readings

13 Authorized User and Radioisotope Safety Issues

Overview

NRC and Other Regulatory Agencies

Types of Licenses

Dose Limits

Radiation Safety Committee

NRC Technical Requirements

Training Required for Use of Unsealed Byproduct Material

Training for Sealed Sources for Diagnosis

Medical Events and Required Reporting

Maintenance of Records

Transportation of Radioactive Materials

Receipt of Radioactive Shipments

Safe Handling and Administration of Radiopharmaceuticals

Generator Breakthrough

PET Radiation Safety

ALARA and Doses to Patients

Release of Individuals After Administration of Radionuclides

Restricted Areas, Radiation Areas, and Signage Posting

Facility Radiation Survey Policies

Waste Disposal

Biological Effects of Ionizing Radiation

Suggested Readings

Self-Evaluation

Unknown Case Sets

Answers to Unknown Case Sets

Answers to Unknown Case Sets

Appendices

Appendix A Characteristics of Radionuclides for Imaging and Therapy

Appendix B.1 Radioactivity Conversion Table for International System (SI) Units (Becquerels to Curies)

Appendix B.2 Radioactivity Conversion Table for International System (SI) Units (Curies to Becquerels)

Appendix C.1 Technetium-99m Decay and Generation Tables

Appendix C.2 Other Radionuclide Decay Tables

Appendix D Injection Techniques and Pediatric Dosages

Appendix E Sample Techniques for Nuclear Imaging

Brain Death or Cerebral Blood Flow Scan

SPECT Brain Perfusion Imaging

Cisternogram

Thyroid Scan (99mTc-Pertechnetate)

Thyroid Scan and Uptake (Iodine-123)

Thyroid Cancer Scan

Parathyroid Scan

Rest Gated Equilibrium Ventriculography

SPECT Myocardial Perfusion Imaging

Exercise Protocol Using a Bruce Multistage or Modified Bruce Treadmill Exercise Protocol

Dipyridamole Pharmacologic Stress Procedure

Adenosine Pharmacologic Stress Procedure

Regadenoson Pharmacologic Stress Procedure

Pulmonary Ventilation Scan (Xenon)

Pulmonary Ventilation Scan (DTPA Aerosol)

Pulmonary Perfusion Scan

Liver and Spleen Scan

SPECT/CT Liver and Spleen Imaging

Hepatobiliary Scan

Meckel Diverticulum Scan

Gastrointestinal Bleeding Scan

Esophageal Transit

Gastroesophageal Reflux/Aspiration

Gastric Emptying

Peritoneovenous (LeVeen) Ascites Shunt Patency

Salivary Gland Imaging

Bone Scan (Technetium-99m)

SPECT Bone Imaging

Bone Marrow Scan

Renal Blood Flow Scan

Renal Scan (A) Cortical Imaging

Renal Scan (B) Glomerular Filtration

Renal Scan (C) Tubular Function

Diuretic (Lasix) Renogram

Captopril Renogram for Diagnosis of Renovascular Hypertension

Radionuclide Cystogram in Children

MIBG Scan for Pheochromocytoma and Neuroblastoma

Gallium Scan for Tumor or Infection

Somatostatin Receptor Scan With Indium-111 Pentetreotide

Lymphoscintigraphy (Sentinel Node Localization)

Molecular Breast Imaging With Breast-Specific Gamma Camera (CZT Detectors)

Leukocyte (White Blood Cell) Scan

PET/CT Tumor Imaging With Fluorine-18 Fluorodeoxyglucose (FDG)

PET Cardiac Imaging With Fluorine-18 Fluorodeoxyglucose (FDG)

PET Brain Imaging With Fluorine-18 Fluorodeoxyglucose (FDG)

PET Amyloid Brain Imaging

PET Cardiac Rest/Stress Imaging With Rubidium-82 or Nitrogen-13 Ammonia

Bone Scan PET/CT (Fluorine-18 Sodium Fluoride)

Red Blood Cell Labeling Techniques

Appendix F Nonradioactive Pharmaceuticals in Nuclear Medicine

Suggested Readings

Appendix G Pregnancy and Breastfeeding

Pregnancy

Breastfeeding

Appendix H.1 General Considerations for Hospitalized Patients Receiving Radionuclide Therapy

Appendix H.2 Special Considerations and Requirements for Iodine-131 Therapy

Nursing Instructions

Release From the Hospital

Appendix I Emergency Procedures for Spills of Radioactive Materials and Special Circumstances

Spills of Radioactive Materials

Minor Spills

Major Spills

Surface Contamination Limits

Emergency Surgery of Patients Who Have Received Therapeutic Amounts of Radionuclides

Emergency Autopsy of Patients Who Have Received Therapeutic Amounts of Radionuclides

Index

Fred A. Mettler, MD, an Elsevier Author, practices diagnostic radiology and nuclear medicine in Albuquerque, where he is Chief of Radiology and Nuclear Medicine at New Mexico Veterans Health Care System. He is currently the U.S. Representative to the United Nations for Radiation Effects.

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